Also available in Core 3 Health
Combats aging at the cellular level.
Much like an atom is the foundation of the universe, a cell is the foundation of the human body. In the quest for long life and optimal health, scientists have delved into the intricate world of cellular function, DNA integrity and energy production. One significant compound stands out amongst the rest as being a crucial part of human metabolism and its aging process: nicotinamide adenine dinucleotide (NAD). Whether we are talking about simple bacteria or the complexity of human metabolism, NAD and its metabolic counterpart NADH are what the cell relies on for life.
These compounds hold the key to supporting healthy metabolism and aging. NAD is a coenzyme that is essential for carrying out cellular and metabolic functions, such as maintaining healthy levels of ATP production within the cells, supporting the body’s cellular regeneration process and supporting healthy mitochondrial metabolism. Prime Anti-Aging Nutraceuticals® NAD+ delivers 250 mg of nicotinamide riboside (NR), paired with 50 mg of pterostilbene, both of which have been scientifically shown to support NAD levels within our cells. NAD is connected to one’s health, youth and quality of life; you simply cannot live without it since it is essential for cellular life. The youth of our cells is associated with our physical and cognitive health and overall well-being. Prime NAD+ is a powerful gluten-free, non-GMO, cutting-edge formula that works to support healthy NAD production and helps maintain NAD levels in aging adults and adults with demanding fitness, work and travel schedules. If it feels like time is always running against you, it's time to consider your energy reserve and NAD. Whether you are looking to combat the natural age-related decline of NAD levels or support NAD levels for those living NAD-depleting lifestyles, the ultimate goal of Prime NAD+ is helping you sustain a healthy reservoir of the youthful NAD molecule.
NAD is naturally occurring; it resides in every living cell in the body and has been shown to be strongly linked to keeping one's youth. Various sources of vitamin B3 are known as precursors of NAD, meaning they influence or help build upon the production of NAD. The balance between the consumption and synthesis of NAD plays into the replenishment or concentration levels of NAD within our cells. There are three pathways that are responsible for helping to maintain this balance, with each one working differently to convert NAD precursors into NAD for our cells. Prime NAD+ is specifically formulated with NR; this precursor is linked to the salvage pathway which plays a unique role in replenishing or restoring the pools of NAD in our cells. NAD+, the oxidized form of nicotinamide adenine dinucleotides, and NADH, the reduced form, make up the NAD+/NADH redox ratio, which provides insight as to how well our cells are creating energy or ATP and portrays the current condition of cellular health and metabolism. NAD-depleting lifestyles can negatively impact this ratio, throwing it off balance, and imbalances of this ratio are associated with cellular aging. Consuming more NAD precursors that promote the increase of NAD is the longevity secret for helping to maintain a healthy balance of this ratio.
Younger people naturally have higher levels of NAD pools in their cells. Additionally, observational research shows that older individuals who do not display the same biomarkers of aging as their age group are also correlated with higher pools of NAD. This demonstrates why sufficient levels are correlated with cell youth and longevity. Studies have shown that the body’s natural NAD production begins to first decrease in skin and within the brain as we age, making these precursors of higher importance to help sustain NAD levels. Other cellular pools also are impacted by age and the loss of NAD; such as mitochondria, adipose tissue and muscle- emphasizing that NAD is a crucial part of healthy aging. Prime NAD+ is formulated with two powerful ingredients, NR and pterostilbene, both of which have scientifically proven their ability to support cellular health. A study analyzing the effects of taking both the precursor NR and pterostilbene for an eight-week period (in which participants were either administered a placebo, a single serving or a double serving of the recommended amount) demonstrated its ability promote an increase of NAD levels. When analyzing concentration of NAD levels in the participants’ blood after four weeks, the study found that the group who took the recommended serving showed a 40% increase and the group who was administered a double serving showed a 90% increase of NAD levels in the blood; the placebo group showed no change. In addition, the levels reported at four weeks remained consistent for both groups who were administered NR and pterostilbene supplementation when measured at 60 days.
While supplementation of NAD precursors is what promotes an extra reserve of NAD, it is NAD itself that really does the heavy lifting and influences all the different working parts of the cell that safeguard you from the inevitable cellular aging process. One influencing factor is the promotion of sirtuins (SIRTs) activity, also known as the “longevity genes.” These genes are enzymes that assist in cellular metabolism and help protect the cells’ state of equilibrium or balance when the cells encounter stress. Prime NAD+ promotes the normal activity of the SIRT-1 gene, a treasured gene that protects the body from the negative effects of free radicals. SIRT-1 is associated with the anti-aging pathways, longevity and the modulation of a whirlwind of processes including DNA repair, genome maintenance, mitochondrial functioning and cellular metabolism. When our DNA becomes damaged, it can deplete the cell’s NAD levels, leading to a decrease in sirtuin activity. Therefore, stockpiling a healthy savings account of NAD naturally makes it easier for our cells to detoxify and aids in preserving the integrity of our genetic blueprint for optimal health.
While maintaining healthy NAD production promotes healthy sirtuin activity, healthy sirtuin activity helps support the of telomeres. Telomeres are genome-protective caps located at the end of chromosomes: they act like the clear coating at the end of a shoelace string that keeps the shoelace from fraying. These little caps can indicate the age or suggested lifespan of a cell, in which the longer in length the telomere is, the better. Each time your cells divide, the chromosomal telomeres become shortened, and over time they inevitably reach the point where the cell can no longer replicate. Evidence shows that shorter telomeres contain lower NAD levels. Just as NAD levels decrease with age, telomeres naturally shorten with age and both are correlated with the health of the cells and their ability to support the body’s cellular regeneration process. Studies suggest that taking both NR and pterostilbene together can support each other's bioavailability, or their ability to be absorbed by the cells. The bioavailability of pterostilbene is an essential factor that promotes the normal activity of the SIRT-1 gene. Pterostilbene also acts as the golden sword for the aging mind, as the autophagy-influencing antioxidant supports the mediation of SIRT-1 and SIRT-2, which may help maintain neurological and cognitive health. In addition, pterostilbene has been shown to be 60% more bioavailable and has a 91 minute longer half-life than its well-known stilbene counterpart, resveratrol; this means that pterostilbene is actively working in your system to assist the cells for a longer period.
Regardless of age, practicing poor lifestyle habits such as smoking, drinking alcohol, lack of sleep or exercise, unhealthy diets and other factors can have depleting effects on maintaining an optimal reservoir of NAD, making NAD-promoting supplementation beneficial for even those who are considered to be younger than the age when metabolic energy may naturally begin to slow down. NR and pterostilbene offer a treasure trove of benefits for our overall well-being and bring you one step further to helping you hack the aging process. With Prime NAD+ on your side, “The golden age is before us, not behind us.” You don’t have to wait until you are aged to start caring about aging.
*These statements have not been evaluated by the Food and Drug Administration. This product(s) is not intended to diagnose, treat, cure, or prevent any disease.
Nicotinamide Riboside (crystalline nicotinamide riboside chloride)
Nicotinamide adenine dinucleotide (NAD) levels naturally decline as we age, and lower levels have been linked to various health issues and the aging process itself. Nicotinamide riboside (NR) is a form of vitamin B3 that functions as a precursor to NAD. When consumed, NR undergoes a series of biochemical reactions, transforming into nicotinamide mononucleotide (NMN), which the body then readily converts into NAD. NAD is a critical coenzyme found in every cell of the body. Its role is to act as a shuttle bus, carrying electrons between molecules in essential steps for many metabolic processes within the cell, namely ATP production – the energy source fueling various cellular functions.
Pterostilbene
Pterostilbene is a naturally occurring compound synthesized in plants. It has a similar structure to the more well-known phenol resveratrol. However, pterostilbene has a longer half-life and the compound has two methoxy groups, giving it a higher bioavailability than resveratrol. Once ingested, it is absorbed into the bloodstream and interacts with various cells and tissues, assisting in several biological pathways. Like resveratrol, pterostilbene has been shown to exhibit antioxidant properties, helping to neutralize harmful free radicals and oxidative stress.
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