Essential Maintenance for Your Maturing Body and Mind

Aging is a reality for us all…the key is to embrace it! This one-two punch of synergistic premium supplements is your best ally to stay active and sharp for the many years ahead. 

Isotonix^® Multivitamin Fifty Plus
Easy to mix and drink, this unique blend of 20 essentials is designed for healthy aging, powerfully supporting your cardiovascular, skeletal, muscle, vision, cognitive and immune health.

Prime™ Cognitin Memory Support Formula
Experience renewed focus and mental clarity with this formula that provides powerful antioxidant support and helps protect against oxidative stress while supporting healthy cognitive function.

Prime™ Cognitin: Made with Prime Ingredients

120 mg
of Gingo Biloba. Prime Cognitin contains a 50:1 ratio of Ginko Biloba, a superior standardized botanical formulated to support healthy blood circulation within the brain.

100 mg
of alpha-lipoic acid, which is about 30% absorbed from dietary or supplemental sources and is reduced to DHLA in many tissues.

FAQs

Why is taking a vitamin supplement important?
A vitamin is an essential nutrient needed for normal metabolism that the body cannot produce and must obtain from external sources. Vitamins help convert food into energy and support growth and tissue repair. Long-term low vitamin levels can cause deficiencies, which may be prevented by proper vitamin intake.

What separates Isotonix^® Multivitamin Fifty Plus from other multivitamins?
Unlike other multivitamin supplements, Isotonix Multivitamin Fifty Plus uses the Isotonix delivery system for efficient nutrient delivery and absorption. This means less nutritional value is lost. It’s specially formulated for older adults, whose bodies absorb nutrients less efficiently with age, ensuring they get key vitamins and minerals like folate, vitamin C, zinc and vitamin B12.

What type of vitamin E is in Isotonix Multivitamin Fifty Plus?
The vitamin E in Isotonix Multivitamin Fifty Plus is the natural, high-activity D-alpha tocopherol. The naturally occurring form of vitamin E. This form of vitamin E is absorbed and retained more efficiently in the body. The natural form of alpha-tocopherol is known as D-alpha tocopherol, whereas the synthetic form is called DL-alpha tocopherol.

Can I take Prime™ Cognitin with food?
Cognitin should be taken with food to improve absorption of the active ingredients.

When should I start to see a difference with Prime Cognitin?
Possibly within two weeks.

What portion of the brain does Cognitin affect?*
Prime Cognitin is formulated to support overall cognitive function and healthy brain function. It is not intended to target a specific region of the brain.

Scientific Studies

• Acetyl-L-Carnitine and Alpha-Lipoic Acid: A Possible Anti-aging Combination Aug 2002, Vol. 8, No. 4: 242-245 
• J Am Geriatric Society. 35(5):425-430, 1987. 
• De Simone, R., et al. Effect of acetyl-L-carnitine on forebrain cholinergic neurons of developing rats. Int J Dev Neurosci. 9(1):39-46, 1991. 
• Pharmacology, Biochemistry and Behavior. 24(4):1123-1128, 1986. 
• Liu, J., et al. Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats. Ann N Y Acad Sci 1033:117-31, 2004. 
• Packer, L., et al. Alpha-lipoic acid as a biological antioxidant. Free Rad Biol Med. 19:227-250, 1995 
• Reed, K. W., et al. Acetylcarnitine and cholinergic receptors. J Pharm Sci. 69:1065-1068, 1980. 
• Taglialatela, G., et al. Neurite outgrowth in PC12 cells stimulated by acetyl-L-carnitine arginine amide. Neurochem Res. 20:1-9, 1995. 
• Wolz, P., et al. Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and protein oxidation in various brain regions of aged rats. J Nutr Biochemistry. 13:619-624, 2002. 
• Rigney U, Kimber S, Hindmarch I. The effects of acute doses of standardized Ginkgo biloba extract on memory and psychomotor performance in volunteers. Phytother Res 1999;13:408-15. View abstract. 
• Subhan Z, Hindmarch I. The psychopharmacological effects of Ginkgo biloba extract in normal healthy volunteers. Int J Clin Pharmacol Res 1984;4:89-93. 
• Kennedy DO, Scholey AB, Wesnes KA. The dose-dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology (Berl) 2000;151:416-23. 
• Mix JA, Crews WD. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Hum Psychopharmacol 2002;17:267-277.. 
• Kaschel, R. Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers. Phytomedicine 11-15-2011;18(14):1202-1207. 
• Rasmussen HM1, Johnson EJ. Nutrients for the aging eye. Clin Interv Aging. 8:741-8, 2013.
• Etten, E., et al. 1,25-Dihydroxycholecalciferol: Endocrinology Meets the Immune System. Proceedings of the Nutrition Society. 61: 375-380, 2002.
• Rink, L. and Kirchner, H. Zinc-Altered Immune Function and Cytokine Production. Journal of Nutrition. 130: 1407S-1411S, 2000.
• Villamor, E. and Fawzi, W. Effects of Vitamin A Supplementation on Immune Response and Correlation with Clinical Outcomes. Clinical Microbiology Reviews. 18: 446-464, 2005.
• Haase H, Mocchegiani E, Rink L. Correlation between zinc status and immune function in the elderly. Biogerontology. 7(5-6):421-8., 2006. Review. 
• Haase H, Rink L. The immune system and the impact of zinc during aging. Immun Ageing. 12;6:9, 2009. 
• Deluca H et al. Vitamin D: its role and uses in immunology. FASEB Journal. 15(14):2579-2585, 2001.
• Hayes C et al. The immunological functions of the vitamin D endocrine system. Cellular and Molecular Biology. 49(2):277-300, 2003.
• Hall, S. and Greendale, G. The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study. Calcified Tissue International. 63: 183-189, 1998.
• Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. Washington, D.C.: National Academy Press; 2000.
• Henning S et al. Glutathione blood levels and other oxidant defense indexes in men fed diets low in vitamin C. Journal of Nutrition. 121:169-175, 1991.
• Johnston C et al. Vitamin C elevates red blood cell glutathione in healthy adults. American Journal of Clinical Nutrition. 58(1):103-105, 1993.
• Frei B et al. Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings of the National Academy of Sciences USA. 86(16):6377-6381, 1989.
• Kirsch M et al. Ascorbate is a potent antioxidant against peroxynitrite-induced oxidation reactions. Evidence that ascorbate acts by re-reducing substrate radicals produced by peroxynitrite. J Biol Chem. 275(22):16702-16708, 2000.
• Burton G et al. Vitamin E: Antioxidant activity, biokinetics, and bioavailability. Annual Review Nutrition. 10:357-382, 1992.

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